Author

Yong-Ying Zhou

2 papers indexed here

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Oct 2026

LGR4 interacts with RhoA to modulate cell survival and epithelial-mesenchymal transition via the Wnt/β-catenin pathway in benign prostatic hyperplasia.

It is demonstrated that LGR4 was overexpressed in BPH and localized within the stromal and epithelial components of prostate and regulated the Wnt/β-catenin pathway by interacting with RhoA to control cellular proliferation, apoptosis and EMT, while barely affected cell cycle.

Ji-Zhang Qiu, Huan Liu, Xiao-Long Ma et al. · Biochimica et Biophysica Act... · 0 citations

Open access Sep 2026

HSPA1A transcriptionally activated by HSF1 facilitates mitophagy via inducing PINK1 phosphorylation to suppress mitochondrial apoptosis in hyperplastic prostate

Benign prostatic hyperplasia (BPH) is a highly prevalent, age-related disorder in men, defined by nonmalignant enlargement of the prostate, which results in bothersome lower urinary tract symptoms and impaired quality of life. Heat shock protein family A member 1 A (HSPA1A)/HSP70, as a molecular chaperone, plays a cr...

Huan Liu, Ji-Zhang Qiu, Huan Lai et al. · Cell Death & Disease · 0 citations