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Yong-Yi Li

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Open access Sep 2026

Priming of CD8+ T cells by peripheral dendritic cells exacerbates tau-mediated neurodegeneration.

Alzheimer's disease and primary tauopathies are marked by changes in adaptive immunity, with increased brain CD8+ T cells correlating with tau pathology severity. However, how peripheral T cells get primed to enter the brain and contribute to tau-mediated neurodegeneration remains unclear. In different disease conditio...

Hao Hu, P. Lin, Carisa Zeng et al. · 0 citations
Review Open access Sep 2026

New insight into Alzheimer’s disease: small molecule-Aβ in the brain transport and peripheral organ clearance

Alzheimer’s disease (AD) represents one of the most prevalent neurodegenerative disorders without approved disease-modifying therapies. A major contributing factor is that, for decades, drug development has focused almost exclusively on repairing or removing lesions within the brain itself. Yet a growing body of work n...

Tian-Ci Ma, Yong-Yi Li, Yu-Ting Ding et al. · 0 citations

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