Author

Yong Tan

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Open access Aug 2026

Reproductive lifespan and cardiovascular health in postmenopausal women: a non-linear, behavior-driven association with cross-population validation

Background Reproductive lifespan (RLS), the interval from menarche to natural menopause, has been associated with cardiovascular disease (CVD) risk. However, most prior studies have assumed a linear relationship, and the potential non-linearity of this association, as well as the underlying behavioral and biological me...

Jie Chen, Jia-Yu Shi, Qian Guo et al. · Frontiers in Medicine · 0 citations

Open access Sep 2026

Amniotic-fluid metabolomics identifies phospholipid remodeling as a metabolic signature of intrauterine exposure in pregnancies with polycystic ovary syndrome

Background Polycystic ovary syndrome is associated with metabolic and hormonal disturbances during pregnancy, but whether these alterations are reflected in the fetal intrauterine exposure environment remains incompletely understood. This study aimed to identify polycystic ovary syndrome-related intrauterine metabolic...

Shi-Ming Wu, Jia-Yu Shi, Chen-Yan He et al. · Frontiers in Endocrinology · 0 citations

Open access Jul 2026

Blunted Lsm14b activation disrupts maternal mRNA remodeling during the GV-to-MII transition in a mouse model of polycystic ovary syndrome

Introduction Polycystic ovary syndrome (PCOS) is the leading cause of anovulatory infertility and is consistently associated with poor oocyte developmental competence, yet the molecular basis of this qualitative defect remains poorly defined. Because the germinal vesicle (GV)-to-metaphase II (MII) transition occurs und...

Wen-Chen Du, Jia-Yu Shi, Jie Chen et al. · Frontiers in Cell and Develo... · 0 citations