Open access
Sep 2026
The E3 ubiquitin ligase IDOL suppresses PRRSV replication by targeting viral Nsp3 for SQSTM1-mediated selective autophagic degradation
An autophagy-dependent antiviral mechanism is uncovered, IDOL is established as an innate immune regulator with a non-canonical function, and a viral immune evasion strategy is defined, positioning IDOL as a promising therapeutic target for PRRSV control.
Jie-Cong Yan, Yu-Han Wu, Hui Xu et al.
· mBio · 0 citations