Aug 2026
UNCX/SIN3A-Mediated H4K8 decrotonylation suppresses FOXO3 to drive TNBC progression and docetaxel resistance.
Uncoordinated homeobox (UNCX) is upregulated in docetaxel-resistant breast cancer cells, genomically amplified in breast cancer, and associated with poor survival in breast carcinoma patients, and established as a pivotal epigenetic regulator of TNBC progression and chemoresistance.
Song-Fu Shi, Dong Yan, Lixin Zhao et al.
· Cellular Signalling · 0 citations