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Author

Yong-Hong Hu

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Open access Sep 2026

Identification and catalytic optimization of pinene oxidases in paeoniflorin biosynthetic pathway

Abstract Paeoniflorin is a pharmacologically important cage-like monoterpene glycoside characteristic of Paeonia plants, yet its biosynthetic pathway has remained largely unresolved, hindering sustainable production. Here, we confirmed that paeoniflorin biosynthesis originates from α-pinene and identified 3 novel cytoc...

Xi-Rui Tan, Xin-Ran Chen, Long-Ji Wang et al. · 0 citations
Open access Sep 2026

Structural insights into a dual-substrate O-methyltransferase reveal the enzymatic mechanism of parallel paeonol biosynthesis

Paeonol, the medicinal indicator component of the traditional Chinese medicine ‘Mudanpi’, has an incompletely elucidated biosynthetic pathway, particularly its post-modification steps. Specifically, the post-modification processes involve 4′-O-methylation and 2′-hydroxylation, thus the formation can occur either sequen...

Xiao-Xiao Zhang, Jun Song, Yi-Ting Wang et al. · 0 citations

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