Yong-gang Ren

Dynamic junction remodeling and transient vascular disruption during cancer cell extravasation across the blood-brain barrier

Brain metastasis is the major cause of cancer-related mortality and remains a critical challenge in clinical oncology. Extravasation of circulating cancer cells across blood-brain barrier (BBB) is the first crucial and rate-limiting step for brain metastasis growth. However, the dynamic changes of brain endothelial cel...