Context‐dependent TREM2 signalling in myeloid cells: Molecular mechanisms and immunotherapeutic divergence in neurodegeneration and cancer
Abstract Background Triggering receptor expressed on myeloid cells 2 (TREM2) is a pivotal lipid‐sensing receptor that governs the functional plasticity and metabolic fitness of mononuclear phagocytes, including microglia, osteoclasts, dendritic cells and tissue‐resident macrophages. While originally identified as a gen...