Stress vulnerability in adolescent mice is characterized by a distinct neurotrophic imbalance in the amygdala and prefrontal cortex.
Adolescence is a critical neurodevelopmental window characterized by heightened plasticity and increased vulnerability to affective disorders. Brain-derived neurotrophic factor (BDNF) signaling through its high-affinity receptor, Tyrosine Kinase B (TRKB), plays a central role in synaptic plasticity and stress adaptatio...