A Site-Specific Organometallic Approach for Installing Tyrosine Phosphorylation Mimics to Decipher the Role of Phosphorylation in α-Synuclein Aggregation and Seeding
This strategy provides a rapid, selective, and scalable way to introduce aromatic PTMs, producing homogeneous protein libraries essential for mechanistic studies, biomarker development, and exploring the therapeutic potential of targeting aSyn-phosphorylation for PD and related disorders.
Shaswati Mandal, Xiao-Yuan Lin, Anastasia V. Gemelli et al.
· Journal of the American Chem... · 0 citations