Review
Aug 2026
Small-molecule inhibitors of SGK1: Structural basis, structure-activity relationships, and therapeutic perspectives.
SGK1 (serum/glucocorticoid-regulated kinase 1) is an AGC family serine/threonine kinase with a pronounced inducible activation profile; its expression and activation are governed by hormonal stimuli and cellular stress. When PI3K-AKT signaling is constrained, SGK1 can function as an alternative node that sustains cell...
Jingjing Xie, Wuyi Wu, Guo-Nian Zhu et al.
· European journal of medicina... · 0 citations