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Microbial cell factories promise sustainable biomanufacturing, yet balancing cellular growth and product synthesis remains a fundamental productivity bottleneck. While traditional static metabolic engineering fails to precisely orchestrate metabolic flux across temporal and spatial dimensions, optogenetic approaches of...
The first compound-protein interaction machine learning model of transporter Vmax and Km, MMTKPred is developed, which captures the effects of point mutations and substrate changes on transporters and effectively models metabolite transport spanning from molecular to multi- species scales.
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