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Author

Yingying Zhu

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Oct 2026

Structural Encoding-decoupled Universal Recognition Enables Amplification-free Multiplex miRNA Detection

Accurate multiplex analysis of microRNAs (miRNAs) remains constrained by enzymatic amplification, spectral crosstalk, and instrumental complexity. Herein, we report a conceptually distinct PhC-SQ platform that integrates photonic crystal (PhC) structural encoding with S9.6-mediated universal recognition for amplifica...

Chang-Can Zhang, Hao Wang, Ying-Ying Zhu et al. · 0 citations
Sep 2026

Engineering post-transcriptional regulation via synthetic membraneless organelles.

Artificial membraneless organelles (MLOs) are emerging as spatial organizers in synthetic biology, yet their applications remain largely confined to post-translational regulation. Here, we engineer synthetic condensates that act as modular hubs for targeted mRNA sequestration, enabling programmable post-transcriptional...

Jun-Tao Ke, L. Wan, Ye-Hong Cao et al. · 0 citations
Review Jul 2026

Recent Advances in The Microbial Synthesis of (-)-α-Bisabolol: Pathway, Enzymes and Strategies.

This review uniquely integrates recent metabolic engineering strategies for enhancing (-)-α-bisabolol production, including chassis cell development, metabolic flux regulation, competitive pathway knockout, cofactors and global regulatory factors optimization, and fermentation scale-up.

Jun-Song Xiao, Zeyu Li, Jiali Zhang et al. · 0 citations
Jul 2026

Systematic modular engineering of genome-integrated Escherichia coli MG1655 for high-level 2'-fucosyllactose production.

2'-Fucosyllactose (2'-FL), the most abundant human milk oligosaccharide (HMO), has attracted considerable interest for its prebiotic and immunomodulatory functions, with broad applications in infant nutrition. In this study, we report the development of a high-yield, genome-integrated 2'-FL-producing strain based on Es...

Rou-Lin Chen, Longhao Yang, Hao Wang et al. · 0 citations

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