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Sep 2026
Trigeminal neuralgia frequently co-occurs with depression, aggravating clinical outcomes. The primary somatosensory cortex (S1), a key pain-processing region, exhibits hyperactivity linked to chronic pain. Moreover, S1 integrates nociceptive inputs to modulate pain-related affective disturbances. However, it rema...
Yuan-Zeng Wang, Tian-En Si, Ying-Ying Zhang et al.
· The Journal of Headache and... · 1 citation
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Open access
Sep 2026
This mechanism-based framework outlines a translational roadmap for personalized neuromodulation, guiding symptom-specific target selection and the development of biomarker-driven, closed-loop DBS systems to concurrently treat pain and affective pathologies.
Tian-En Si, Hao Han, Ying-Ying Zhang et al.
· iScience · 0 citations
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Aug 2026
BACKGROUND
The nucleus accumbens (NAc) integrates affective and sensory information crucial for pain processing. While canonically viewed as a predominantly GABAergic structure, the potential existence and function of non-canonical excitatory populations remain poorly understood. We hypothesized that a distinct subpopu...
Tian-En Si, Zhi-Xiao Li, Ying-Ying Zhang et al.
· Regional anesthesia and pain... · 0 citations
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