Author

Ying-Ying Meng

2 papers indexed here

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Sep 2026

Abstract B018: PPM1D- versus TP53-altered H3K27M-altered diffuse midline gliomas define distinct tumor states with isogenic modeling of Ppm1d-driven replication stress

H3K27M-altered diffuse midline glioma (DMG) is an aggressive pediatric brain tumor for which radiation is standard of care but only transiently delays progression. The oncogenic phosphatase PPM1D and the tumor suppressor TP53 both regulate DNA-damage-response (DDR) circuitry and are frequently mutated in H3K27M-alter...

Kate J. Lee, Abigail J. Groth, Ying-Ying Meng et al. · Cancer Research · 0 citations

Open access Sep 2026

FANCM is required for the PAX3::FOXO1-driven oncogenic program in rhabdomyosarcoma.

Many cancers are driven by mutationally altered transcription factors (TFs) that rewire cells to an oncogenic state. Cells must activate specific mechanisms to tolerate the burden of oncogenic TF activity. To define such mechanisms, we focused on a canonical oncogenic fusion protein-driven cancer, alveolar rhabdomyosar...

C. Delaney, Min Lu, S. Zimmerman et al. · Cell Reports · 0 citations