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Author

Yingxin Yang

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Open access Oct 2026

A dual-action bacteriophage protein Ped1 degrades DNA and blocks replication in Pseudomonas aeruginosa.

To fully harness phage therapy against escalating antimicrobial resistance, it is imperative to elucidate the fundamental mechanisms by which viruses systematically dismantle host physiology. In this study, we identify Ped1, a protein from Pseudomonas aeruginosa phage PaoP5, which suppresses bacterial growth through tw...

Tie-Tao Wang, Wen-Bo Yan, Chen-Chen Wang et al. · 0 citations
Open access Jul 2026

Bacteriophage genome-wide transposon mutagenesis

Summary Bacteriophage genomes are densely packed with coding sequences and frequently encode genes of unknown function. Unbiased phage functional genomics approaches are therefore needed, particularly for large lytic phages. Here, we harness the mariner transposase to develop phage transposon mutagenesis and sequencing...

A. Chan, Wearn-Xin Yee, Deepto Mozumdar et al. · 0 citations

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