Xenocoumacin 1 (Xcn1), a dihydroisocoumarin-derived antimicrobial natural product from Xenorhabdus nematophila CB6-T2, exhibits broad-spectrum antifungal activity, yet its antibacterial mechanism remains unknown. This study evaluated the antibacterial spectrum of Xcn1 against 13 bacterial strains, with Ralstonia sola...
Liu Yang, Yanping Lei, Jin-Cheng Ma et al.· Journal of Agricultural and...· 0 citations
In pursuit of environmentally friendly agrochemicals, we employed the natural quinine alkaloid scaffold as a lead for the design and synthesis of three series of structurally diverse quinine derivatives and systematically evaluated their in vitro antibacterial and antifungal activities. Among them, compounds Ka9 and Ka...
Lu-Lu Qin, Gui-Ping Gao, Shi-Ya Guan et al.· Journal of Agricultural and...· 0 citations
Trehalose-6-phosphate phosphatase (TPP), a key enzyme in trehalose biosynthesis, represents a promising target for pest and fungal control due to the absence of TPP in higher animals. However, few TPP inhibitors have been reported, and broad-spectrum agents targeting both insects and fungi remain scarce. In this stud...
Xi Jiang, Mingjia Gao, Zhijun Zhang et al.· Journal of Agricultural and...· 0 citations
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