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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Ying-Qian Gao

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Open access Sep 2026

Toxoplasma gondii infection disrupts secondary bile acid transformation in feline gut microbiota

ABSTRACT Bile acid (BA) transformation relies on gut microbiota and is vulnerable to Toxoplasma gondii infection, yet feline microbial BA-transforming capacity upon toxoplasmosis remains unclear. Here, we constructed a catalog of 2,474 nonredundant feline gut microbial genomes and integrated serum metabolomic data to v...

Lu-Yao Tang, He Zhang, Ji-Xin Zhao et al. · 0 citations
Aug 2026

Untargeted metabolomics reveals L-Lysine depletion as a host-directed therapeutic target in Toxoplasma gondii infection.

Toxoplasmosis is a widespread zoonotic disease causing severe outcomes in immunocompromised individuals and during pregnancy. Current therapeutic options target actively replicating stages of the parasite and show limited efficacy against chronic infection. While research has focused on parasite-directed therapies, hos...

Xue-Yao Wang, Ji-Xin Zhao, Xiao-Tong Chen et al. · 1 citation

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