Sep 2026
Chlorinated chaetoviridin-type azaphilones discovered via metabolomics: structural diversity and suppression of STAT3 signaling in gastric cancer cells.
Azaphilones are structurally diverse polyketides with broad bioactivities, among which chaetoviridins are distinguished by their chlorinated frameworks and anticancer potential. To expand the chemical space of STAT3-relevant azaphilones, a metabolomics strategy integrated with OSMAC (one strain many compounds) fermenta...
Wei-Yi Wang, Lin-Tao Zheng, Lai-Xi Luo et al.
· Bioorganic chemistry (Print) · 0 citations