Background: Endothelial defects in the heart are a contributor to cardiac pathological remodeling and dysfunction, which can be influenced by cardiomyocytes (CMs). Here, we explore cardioprotective crosstalk between CMs and endothelial cells (ECs) under diabetic conditions. Methods: Type 2 diabetes mellitus (T2DM) was...
S. Gare, N. H. Alatawi, Xin-Yi Chen et al.· Circulation Research· 0 citations
This review summarizes recent advances in 3D cardiac in vitro modeling technologies, outlines major cardiac model construction strategies and their technical characteristics, and discusses their applications in drug toxicity evaluation, high-throughput drug screening, disease modeling, and personalized medicine.
Xiao-Ying Liu, Ying-Juan Liu, Yu-Tong Yan et al.· International Journal of Dru...· 0 citations
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