Mechanisms underlying the immunosuppressive microenvironment in hepatocellular carcinoma (HCC) extend beyond immune checkpoints to include metabolic competition. Here, we identify a metabolic evasion pathway driven by SLC1A5 overexpression, which enables HCC cells to sequester glutamine from the tumor microenvironmen...
Jingjing Nian, Zi-Ran Wang, Shi-Yi Chen et al.· Cell Death & Disease· 0 citations
This urine-based model enables dynamic assessment of tumor burden and early recurrence detection, surpassing conventional serum biomarkers and providing a clinically actionable tool for personalized surveillance and therapeutic decision-making in HCC.
Xiao-Hua Xing, En Hu, Lei Song et al.· Molecular & Cellular Proteom...· 0 citations
RNA sequencing of lenvatinib-resistant HCC cell lines revealed p53 dysregulation, and sanger sequencing identified the p53 R280S missense mutation, which was shown to enhance lenvatinib resistance in vitro and in vivo.
Niangmei Cheng, Ke-Xin Liu, Xin Qi et al.· Molecular and Cellular Bioch...· 0 citations
It is found that lncRNA MKRN3-AS1 was dramatically upregulated in HCC tissues and associated with poor prognosis, and may be a potential prognostic biomarker and therapeutic target for HCC.
Fei Wang, Ji-Zhe Liu, Gao-Xiong Wang et al.· Scientific Reports· 0 citations
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