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Author

Yinqing Li

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Oct 2026

Silencing the mutant allele without compromising gene dosage.

Allele-selective silencing offers a strategy to suppress pathogenic alleles in dominant genetic disorders but may alter total gene dosage when the remaining allele does not compensate. Wang et al.1 show that SNP-guided epigenetic repression of mutant alleles can elicit compensatory expression from non-targeted alleles,...

Lu Tian, Jun-Han Chen, Yin-Qing Li · 0 citations
Open access Aug 2026

Ultra-sensitive profiling of CRISPR-Cas off-target effects with Tracking-seq2

Track-seq2 provides a robust platform for sensitive off-target detection in primary cells, with sensitivity comparable to or exceeding current state-of-the-art methods.

Ting-Ting Cong, Run-Da Xu, Xuan-Cheng Chen et al. · 0 citations

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