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Author

Yikun Wang

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Aug 2026

LZTFL1 rewires NADPH-glutathione metabolism to amplify ferroptosis.

Ferroptosis, a form of oxidative cell death, represents a therapeutic vulnerability for treating apoptosis-resistant cancers. Here, we identify leucine zipper transcription factor-like 1 (LZTFL1) as a key regulator of ferroptosis that rewires glutathione (GSH) metabolism. Mechanistically, LZTFL1 promotes oxidation of g...

Xiangfei Xue, Xiao Zhang, Qianjun Zhou et al. · 0 citations

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