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Yi-Jun Zhang

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Review Open access Jul 2026

Development, applications, and future prospects of RNA virus reverse genetics technology

This review systematically summarizes the evolution, technical framework and optimization strategies of RNA virus reverse genetics, with three prototype viruses covering all major RNA genome types: SARS-CoV-2 (+ssRNA), non-segmented negative-sense Newcastle disease virus (NDV), and segmented negative-sense influenza A virus.

Yu Guo, Ting Xue, Jianhua Wang et al. · 0 citations

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