Yichen Henrry Liu

CNVeil resolves haplotype-specific copy number and uncovers subclonal architecture hidden from total copy number profiling in single-cell cancer genomes

CNVeil provides a scalable framework for studying tumor evolution and functional genomic heterogeneity at single-cell resolution and consistently outperformed existing tools in segmentation accuracy, ploidy inference, subclone identification, and allele-specific copy number estimation.