Author

Yi-Yuan Wang

2 papers indexed here

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Review Aug 2026

AKAP12 as a signal-compartmentalizing Hub across diseases: Context-dependent functions and translational potential.

A-kinase anchoring protein 12 (AKAP12; Gravin/SSeCKS) is a multidomain scaffold that coordinates spatially restricted signaling rather than acting as a single linear effector. By organizing protein kinase A (PKA), protein kinase C (PKC), phosphodiesterases (PDEs), proto-oncogenic non-receptor tyrosine kinase (Src)-rela...

Jiao Tian, Yuyuan Lu, Tao Wu et al. · Cellular Signalling · 0 citations

Review Open access Sep 2026

Cell-state- and compartment-dependent PI3K/Akt redox signaling in chronic kidney disease: mechanisms and translational implications

This review examines PI3K/Akt-mediated redox regulation across four dimensions: redox inputs, organellar microdomains, renal cell states, and clinical translation, while discussing therapeutic strategies tailored to specific cell states and spatial compartments.

Jian-Zong Xuan, Ren-Hua Ding, Hai-Ying Zhang et al. · Frontiers in Pharmacology · 0 citations