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Author

Yi-Ying Zhang

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Open access Sep 2026

Genetically supported targets and drug repurposing for sleep disorders: a Mendelian randomization systematic study.

Sleep disorders present major public health issues because of their associations with chronic diseases. Despite extensive research efforts, the underlying biological mechanisms remain inadequately understood. We performed bidirectional two-sample Mendelian randomization (MR) to investigate relationships between sleep d...

Zi-Yu Wang, Miao Zhang, Cong Liu et al. · 0 citations
Aug 2026

Single-cell transcriptomic analysis reveals systemic immune dysregulation and identifies PLEK as a candidate hub gene associated with CD8+ T-cell activation in myasthenia gravis.

This study provides a systems-level view of immune dysregulation in MG, highlighting enhanced intercellular communication, T-cell dysregulation, and PLEK as a potential molecular marker associated with CD8+ T-cell activation and disease severity, offering insights into MG pathogenesis and therapeutic targets.

Jing-Nan Jin, Zi-Hong Chen, Yi-Ying Zhang et al. · 0 citations

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