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NINJ1 Defines a Hyperinflammatory Monocyte State Associated with Severe COVID-19
Background/Objectives: Severe coronavirus disease 2019 (COVID-19) is characterized by dysregulated immune activation and excessive inflammation; however, the specific immune cell states that drive disease progression remain incompletely understood. Methods: Here, we integrated single-cell RNA sequencing analysis of per...
IL1R2⁺ Inflammatory Monocytes Contribute to Immune Dysregulation and Predict Mortality in COVID-19.
IL1R2 identifies a highly inflammatory monocyte state associated with COVID-19 immune dysregulation, supporting its potential role as a complementary prognostic biomarker and therapeutic target.