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MMX and MVX are independently associated with incident AD, supporting the clinical relevance of metabolic health monitoring in neurodegeneration risk stratification.
Higher UPF consumption is associated with increased atherosclerosis risk and support dietary recommendations emphasizing minimally processed foods for cardiovascular disease prevention and highlight candidate molecular correlates requiring independent validation.
This review examines how tumor-derived signals activate IRE1α/XBP1 to upregulate both the autophagy-lysosome pathway (ALP) and ubiquitin-proteasome system (UPS); its crosstalk with inflammatory and metabolic networks; and the therapeutic potential of IRE1α inhibitors, XBP1-directed strategies, and nutritional approache...
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