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Sep 2026

Targeting ClpP Rewires the Metabolic-Immune Axis in Acute Myeloid Leukemia.

Acute myeloid leukemia (AML) critically depends on oxidative phosphorylation (OXPHOS). Mitochondrial targeted therapies are advancing into clinical trials, but metabolic vulnerabilities have been primarily explored from a tumor-intrinsic perspective. Leukemic cells can actively reshape an immunosuppressive tumor microe...

Xin-Rong Xiang, Bao-Zhu Luo, Lei Zhao et al. · 0 citations
Review Open access Sep 2026

Harnessing tumor immune checkpoints for autoimmune disease therapeutics

Immune checkpoint (IC) pathways, originally identified in T-cell exhaustion in cancer, are increasingly recognized as key modulators of immune tolerance in autoimmune diseases (ADs). In ADs, these molecules function more accurately as inhibitory receptors (IRs) that fine-tune, rather than inducing classical exhaustion...

Han-Mei Yang, Ping Zhang, Yi Wu et al. · 0 citations

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