Author

Yi-tao Liao

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Open access Sep 2026

A microbiota-substrate-metabolite-target network suggests AKT1-associated links between gut microbiota-derived metabolites and osteoporosis.

OBJECTIVE To build a computational, hypothesis-generating framework that links gut microbiota-related metabolites with osteoporosis (OP) while retaining upstream microbial source and substrate information, and to prioritize candidate host targets, pathways, and modules for subsequent testing. METHODS Metabolites and...

Wen-Xing Zeng, Yuan Gong, Yi-Tao Liao et al. · International Microbiology · 0 citations

Review Open access Aug 2026

Rewiring osteoimmune homeostasis in osteoporosis: T-cell subsets as key regulators and emerging therapeutic targets

A narrative synthesis of current evidence about the molecular mechanisms by which T-cell subsets regulate osteoporosis-related bone remodeling, the features of immune imbalance in different types of osteoporosis, T-cell-targeted intervention strategies, and translational challenges is provided to provide a theoretical...

Yuan Gong, Wen-Xing Zeng, Yi-Tao Liao et al. · Frontiers in Immunology · 0 citations

Open access Aug 2026

Segment-specific prediction of vertebral collapse severity in osteoporotic fractures

Background Osteoporotic vertebral compression fractures (OVCFs) predominantly cluster at the thoracolumbar junction (T11-L1). Recent studies suggest that both bone quality and muscle health significantly contribute to vertebral collapse. However, among numerous multidimensional imaging metrics, which one can most accur...

Yi-tao Liao, Xing-Guo Zhang, Xuanyu Xie et al. · Frontiers in Endocrinology · 0 citations