Open access
Jul 2026
The transcription factor IRF8 promotes the survival of differentiated effector CD8 T cells 2254435
CD8+ T cells depend on IL-2 signals to drive effector differentiation and sustain clonal expansion, yet how IL-2—responsive transcription factors coordinate these outcomes remains incompletely defined. The transcription factor IRF8, previously known for roles in myeloid and B-cell lineage reinforcement, is highly...
Uddeep Chaudhury, Alayna M. Rosales, Zoe K. Bedrosian et al.
· Journal of Immunology · 0 citations