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Author

Yi Shao

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Aug 2026

UCHL1 attenuates diabetic retinopathy by deubiquitinating and stabilizing NRF2 to suppress oxidative stress-induced retinal vascular endothelial ferroptosis.

The UCHL1/NRF2 axis may represent a therapeutic target in DR and co-immunoprecipitation and ubiquitination assays demonstrated that UCHL1 interacted with NRF2 and stabilized NRF2 by removing K48-linked polyubiquitin chains.

Sanhua Xu, Jun Huang, Yi-Cang Wang et al. · 0 citations

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