Aug 2026
UCHL1 attenuates diabetic retinopathy by deubiquitinating and stabilizing NRF2 to suppress oxidative stress-induced retinal vascular endothelial ferroptosis.
The UCHL1/NRF2 axis may represent a therapeutic target in DR and co-immunoprecipitation and ubiquitination assays demonstrated that UCHL1 interacted with NRF2 and stabilized NRF2 by removing K48-linked polyubiquitin chains.
Sanhua Xu, Jun Huang, Yi-Cang Wang et al.
· Biochemical Pharmacology · 0 citations