Author

Yi-Ran Xu

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Open access Sep 2026

Atg7 deficiency in Tmem119-Cre-targeted cells causes sustained neuroimmune dysregulation and disrupts early postnatal brain development

Autophagy is a critical regulator of immune homeostasis, but the role of autophagy-related gene 7 (Atg7) in microglia during early postnatal brain development remains incompletely understood. Here, we investigated how Atg7 deficiency in Tmem119-Cre-targeted brain cells influences postnatal neuroimmune homeostasis...

Liu-Jing Chen, Yu Yang, Bo Hu et al. · Journal of Neuroinflammation · 0 citations

Open access Sep 2026

ROS-responsive hydrogel delivering liposomal indole-3-propionic acid promotes spinal cord injury repair by enhancing CX3CL1-CX3CR1 mediated neuron-microglia communication

Spinal cord injury (SCI) is a devastating neurological disorder characterized by excessive neuroinflammation and limited regenerative capacity. Here, we developed a reactive oxygen species (ROS)-responsive hydrogel for localized delivery of liposomal indole-3-propionic acid (IPA), a gut microbiota-derived metabolite wi...

Long-Yu Li, Yu-Hao Zhang, Zhi-Shuo Wang et al. · Materials Today Bio · 0 citations

Open access Aug 2026

Neonatal inflammation disrupts a temporally restricted postnatal Numb-enriched microglial state in mice

Early-life microglia are diverse and support brain development beyond immune surveillance, but the transient states associated with postnatal maturation remain poorly understood. Here we show, using a time-resolved single-cell atlas of neonatal mouse brain immune cells, that a postnatal Numb-enriched microglial state e...

Jin-Jin Zhu, Yi-Ran Xu, Liu-Bo Sun et al. · Nature Communications · 0 citations