Author

Yi-Qiang Zhu

2 papers indexed here

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Open access Aug 2026

Decitabine suppresses triple-negative breast cancer by disrupting DNMT1 liquid-liquid phase separation and synergizes with G9a inhibition

Triple-negative breast cancer (TNBC) remains a substantial clinical challenge due to the lack of well-defined therapeutic targets. Previous studies have demonstrated that epigenetic modifiers play crucial roles in the progression of various cancers. In this study, we identify DNA methyltransferase 1 (DNMT1) as a critic...

Mei-Lin Hu, Hao-Jie Peng, Guo-Chang Qiu et al. · Oncogene · 0 citations

Open access Sep 2026

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

ABSTRACT Coronaviruses have persistently triggered global pandemics in the 21st century, featuring either high transmissibility or high pathogenicity. A hallmark of these infections is the delayed activation of innate immune responses, resulting in dysregulated antiviral signaling and uncontrolled viral replication. Mu...

Li-Xiang Xie, Zi-Ye Huang, Zhi-Yuan Zhang et al. · Advancement of science · 0 citations