Author

Yi-Ping Huang

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Review Open access Sep 2026

Inhibitory receptor profiles for joint prediction of benefit and toxicity in immune checkpoint blockade

Summary Immune checkpoint blockade has transformed cancer therapy, but durable benefit is limited to a subset of patients and can be accompanied by immune-related adverse events. This Review evaluates inhibitory receptor profiles as candidate biomarkers for predicting both antitumor benefit and immune toxicity. We exam...

Xiao-Dong Wang, Di Xiong, Bing-Chen Duan et al. · iScience · 0 citations

Review Open access Jul 2026

Ecosystem-matched reprogramming of the tumor–immune microenvironment to overcome cancer immunotherapy resistance

It is proposed that future progress will depend on ecosystem-matched combinations guided by spatial biomarkers, on-treatment pharmacodynamics, and adaptive trial designs capable of linking mechanism to clinical decision-making.

Xiao-Dong Wang, Qian-Qian Wang, Wei-Yi Gao et al. · Molecular Cancer · 0 citations