Author

Yi-Mo Deng

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Open access Oct 2026

Bovine myxovirus resistance protein (Mx)1, but not Mx2, mediates antiviral activity against human and avian influenza A viruses, including H5N1 clade 2.3.4.4b

ABSTRACT Highly pathogenic avian influenza (HPAI) H5N1 clade 2.3.4.4b viruses have recently infected dairy cows in the United States, raising concerns about human spillover. The antiviral roles of bovine host defense factors, including myxovirus resistance proteins (bMx1 and bMx2), remain relatively understudied. We ex...

Rubaiyea Farrukee, Yong-Yan Xia, Rachel Morris et al. · Journal of Virology · 0 citations

Open access Sep 2026

A Cluster of Influenza A(H3N2) Viruses in 2024 From Tasmania, Australia, With Reduced Susceptibility to Baloxavir

The emergence of viruses with reduced susceptibility to antivirals poses an ongoing risk which could limit their effectiveness. Here we report a cluster of A(H3N2) viruses detected in Tasmania, Australia, with a PA gene mutation A37T that showed mild reductions in susceptibility in vitro to baloxavir (3.47‐ to 16.33‐fo...

Saira Hussain, Charmaine Chia, Ashwin Muraleetharan et al. · Influenza and Other Respirat... · 0 citations

Open access Jul 2026

Epistasis facilitates the long-term antigenic evolution of the influenza B virus hemagglutinin

This study identifies critical similarities and differences with A(H3N2) evolution and demonstrates the role of epistasis in balancing antigenic novelty with viral fitness, and supports the development of genotype-to-phenotype prediction tools, but such predictions need to capture the complex outcomes of epistasis.

Lara S. U. Schwab, Ruo-Peng Xie, Ellie Reilly et al. · bioRxiv · 0 citations