Author

Yi-Ming Zhong

3 papers indexed here

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Open access Oct 2026

Genomic epidemiology reveals niche specialization and a virulence-resistance trade-off in ST23 and ST11 hypervirulent Klebsiella pneumoniae.

OBJECTIVES The convergence of hypervirulence and carbapenem resistance in Klebsiella pneumoniae poses a critical public health threat, yet the comparative genomic characteristics and adaptation patterns of dominant clones ST23 and ST11 in clinical settings remain unclear. This study aimed to characterize their divergen...

Fang Yang, Qin-Rui Lai, Wen-En Liu et al. · International Journal of Inf... · 0 citations

Oct 2026

LNA Blocker-Enhanced Multiplex Chip-Based Digital PCR for Ultrasensitive Quantification of Liver-Specific DNA Methylation in Plasma

Sensitive and selective quantification of rare methylated DNA in plasma remains a major analytical challenge. For methylation targets located in CpG-sparse regions, bisulfite conversion produces only subtle sequence differences between methylated and unmethylated alleles, thereby hindering selective amplification. He...

Yan-Ping Lan, Xin Yang, Tian-Bin Chen et al. · Analytical Chemistry · 0 citations

Open access Sep 2026

Humanin Attenuates Inflammatory Liver Injury and NF-κB Activation During Systemic Hypervirulent Klebsiella pneumoniae Infection

Hypervirulent Klebsiella pneumoniae (hvKP) causes invasive infections, including bloodstream infections and liver abscesses, and dysregulated host inflammation may exacerbate liver injury. We investigated whether pretreatment with Humanin, a mitochondria-derived anti-inflammatory peptide, could attenuate hvKP-associate...

Yi-Ming Zhong, Dina Haishaer, Wei-Dong Cai et al. · Pathogens · 0 citations