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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Yi Luo

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Jul 2026

SLFN11 binds DDX1 to counteract human mesenchymal stem/stromal cell senescence through inhibition of mTOR/eIF4E signaling pathway activation.

A non-canonical role for SLFN11 safeguarding MSCs from senescence via the DDX1/mTOR/eIF4E axis is delineated and SLFN11-overexpressing MSCs constitute a promising and safe cell therapy source, characterized by preserved pluripotency and augmented therapeutic efficacy.

Xin-Xin Zhu, Yi Luo, Jin-Yan Xu et al. · 0 citations

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