Author

Yi Luo

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Open access Aug 2026

Dioscin extends lifespan and ameliorates aging associated phenotypes in association with the endoplasmic reticulum unfolded protein response.

Dioscin, a naturally occurring steroidal saponin isolated from various kinds of herbs with pleiotropic pharmacological properties, remains mechanistically undefined regarding its mammalian aging modulation. This study discovered that dioscin extended the lifespan of Caenorhabditis elegans. Concurrently, dioscin improve...

Yi Luo, Nian Jiang, Xiaocong Li et al. · Experimental Gerontology · 0 citations

Sep 2026

LASS2 alleviates liver fibrosis by interacting with THBS1, TFRC, and APOE to inhibit TGF-β1 signaling and ferroptosis, and by reshaping the hepatocyte lipid secretome to suppress paracrine HSC activation.

BACKGROUND Liver fibrosis (LF) lacks effective therapies. Longevity assurance homolog 2 (LASS2), a key ceramide synthase, contributes to liver homeostasis, but its role in LF remain unclear. METHODS Bioinformatics revealed LASS2 correlation with classic fibrotic factors, and its expression was assessed in fibrotic mo...

Rong-Jin Yu, Xiao-Yu Li, Yun-Fei Huang et al. · Cellular Signalling · 0 citations

Open access Sep 2026

Nasal exposure to PM2.5 induces testicular injury and activation of pyroptosis-related signaling in rats: Inhibitor intervention and public transcriptomic analysis

Exposure to PM2.5 significantly elevated the levels of several testicular proteins, including NLRP3, ASC, cleaved caspase-1, cleaved caspase-1, cleaved caspase-3, GSDMD-N, total caspase-1, and full-length GSDMD, whereas cleaved caspase-3 did not differ significantly.

Yi Luo, Cao Wang, Meng-Xi Tian et al. · PLoS ONE · 0 citations