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Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

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Yi-Lun Sun

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Open access Sep 2026

Sensitizing tumor response to topoisomerase I antibody-drug conjugate by selective CDK7 inhibition

This study investigates the transcriptional impact of Q901, a highly selective cyclin-dependent kinase 7 (CDK7) inhibitor in clinical development. Q901 primarily disrupted MYC and E2F-dependent transcription programs, down-regulating cell cycle control and DNA damage repair pathways. CDK7 binding at the promoter-proxim...

Hyerim Jung, Yoonji Lee, Donghoon Yu et al. · 0 citations
Open access Aug 2026

Genome-wide mapping reveals increased R-loops in topoisomerase III-beta-deficient human cells

Summary Aberrant R-loops can cause genomic DNA damage. We mapped R-loops across the genomes of human colon carcinoma HCT116 and fibrosarcoma HT1080 cells deficient for topoisomerase III-beta (TOP3B) by performing DNA-RNA immunoprecipitation followed by high-throughput sequencing (DRIP-seq). Knocking out TOP3B globally...

Sourav Saha, A. Dhall, Shar-yin N. Huang et al. · 0 citations

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