Author

Yi-Lin Fang

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Open access Oct 2026

Spontaneous wbbL and waaG mutations selected by phage vB_EcoP_P61425 confer resistance and attenuate virulence in ExPEC

Bacteriophage therapy is a promising strategy against multidrug-resistant (MDR) extraintestinal pathogenic Escherichia coli (ExPEC), yet bacterial resistance evolution remains a major clinical challenge. In this study, we isolated and comprehensively characterized a novel lytic phage, vB_EcoP_P61425, belonging to t...

Long Chen, Si-Xiang Xu, Xiao-Yue Li et al. · Frontiers in Microbiology · 0 citations

Aug 2026

An immunoinformatics-based multi-epitope vaccine candidate confers cross-protection against two Actinobacillus pleuropneumoniae serovars.

MVAPP represents a potential multi-epitope vaccine candidate for further development against APP and elicited specific antibody responses, shifted the splenic T-cell subset distribution toward CD4+ T cells, and provided partial protection against challenge with strains from two serovars.

Libin Tan, Yi-Lin Fang, Pei-Fan Liu et al. · Vaccine · 0 citations

Open access Jul 2026

IFIT1+ Tumor-Associated Macrophages Suppress Cancer Stemness and Enhance Chemosensitivity via the TNFSF10-TNFRSF10B Axis in Epithelial Ovarian Cancer.

These insights shed light on the functional diversity of macrophages, highlighting that driving tumor-associated macrophages toward a sustained, interferon-primed IFIT1+ phenotype represents a promising therapeutic approach to target cancer stem cell populations in epithelial ovarian cancer.

Rui Liu, Yi-Lin Fang, Ru-Xin Zheng et al. · Frontiers in Bioscience · 0 citations