Open access
Sep 2026
Mycn facilitates hematopoietic stem and progenitor cell generation from endothelial cells by inhibiting adhesion signaling.
It is demonstrated that endothelial-specific deletion of Mycn, but not Myc, impairs HSPC formation in mouse embryos and uncovers a regulatory mechanism whereby Mycn promotes HSPC generation from endothelial cells by suppressing adhesion signaling.
Chi Wang, Zhe Chen, Mei-Lin Jiang et al.
· Cell Reports · 0 citations