Yi-He Zhang

Targeting tumour-neuron synapses with intracavitary RNA delivery prevents glioblastoma recurrence.

Tumour-neuron interactions and malignant synapse formation drive glioblastoma progression, recurrence and neurological dysfunction, but systemic inhibition of synaptic signalling causes unacceptable neurotoxicity. Here we defined the spatial and molecular determinants of malignant synapses by analysing intact human gli...