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Yi-Fu Song

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Oct 2026

NFAM1 organizes a lipid raft-restricted DAPP1-PLCG2 module to drive M2-like GAM polarization via Ca²⁺-NFAT1 signaling in glioma.

BACKGROUND Glioma-associated macrophages (GAMs) promote glioma progression, but the membrane-proximal mechanisms sustaining their tumor-supportive states remain poorly defined. METHODS Bulk and single-cell transcriptomic analyses, human glioma specimens, GAM models, and orthotopic glioma models were used to define th...

Yao-Chuan Zhang, Rong-Jin Chen, Yi-Fu Song et al. · 0 citations

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