Oct 2026
SmartPE enables efficient prime editing in dicot crops.
Yi-Jing Liu, Chao Sun, Hu Xu et al.
· Nature Plants · 0 citations
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Engineered genomic attachment sites for site-specific recombinases enable high-efficiency integration in plants and human cells.
Here we developed a DNA-centric strategy for optimizing site-specific recombination by rationally engineering chimeric attachment sites. The high-activity att variants enhance Bxb1-mediated integration efficiency in human cells and plants. Among these att variants, the engineered attB(V111) site achieved 51.9% integrat...
Lin-Li Yan, Ling Zhou, Qiang Gao et al.
· Nature Biotechnology · 0 citations