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Open access Sep 2026

Epi-Allele elicits compensatory expression of the non-targeted allele and prevents haploinsufficiency in dominant genetic diseases.

Epigenetic regulation may underlie asymmetric allelic expression of many genes during development and disease pathogenesis. Allele-specific epigenetic modification could provide an efficient therapy for dominant genetic diseases due to heterozygous mutations. We developed an allele-specific epigenetic editing method ("...

Zheng-Min Wang, Cheng-Zhi Han, Yi-Ming Huang et al. · 1 citation
Open access Sep 2026

Phosphoregulation of hierarchical protein condensate formation during clathrin-mediated endocytosis

The sequential assembly of over 50 proteins during clathrin-mediated endocytosis (CME) is well documented in yeast. However, the mechanisms governing this ordered recruitment remain poorly understood. Biomolecular condensation is proposed to orchestrate CME, but defining biophysical parameters in vivo remains challengi...

Yi-Di Sun, Andrew Wong, Ge-An Hu et al. · 0 citations
Open access Aug 2026

The cellular and molecular basis of gyrus-sulcus specialization in the primate brain

How differences in brain cell composition help define cortical folds are uncovered and a link between microscopic cellular organization and large-scale brain networks in primates is revealed.

Ying-Guang Bai, Tao Song, He Wang et al. · 0 citations

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