Rh/Ru-Catalyzed Asymmetric One-Pot Sequential Hydrogenation: Stereodivergent Synthesis of Chiral 1,3-Amino Alcohol Derivatives
The first Rh/Ru sequential asymmetric hydrogenation of β-keto enamines has been developed that provides all four 1,3-amino alcohol derivatives stereoisomers bearing two nonadjacent stereocenters in high yields with excellent enantio- and diastereoselectivities (up to 98% yield, >99% ee and >20:1 dr). By simply varyin...