Spatial transcriptome and single-cell reveal the role of sorbitol metabolism in hepatocellular carcinoma progression and tumor microenvironment.
The mechanistic role of sorbitol metabolism in driving HCC progression through shaping an immunosuppressive microenvironment is uncovered and the sorbitol metabolism scoring system may serve as a novel prognostic biomarker and provides a theoretical foundation for precision treatment strategies, such as Irofulven-targe...