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Aug 2026

Structural insights into the ADP-bound p97/VCP ND1 hexamer revealed by room-temperature XFEL crystallography.

p97/VCP ATPase uses adenosine triphosphate (ATP) hydrolysis to remodel protein assemblies and unfold substrates across diverse cellular processes, including protein quality control, membrane fusion, and chromatin regulation. Although cryogenic structural studies have provided valuable snapshots of distinct nucleotide s...

Seri Koh, H. Jeon, Eunsoo Lee et al. · 0 citations
Open access Aug 2026

Spatially fractionated radiotherapy with PD-L1 blockade achieves superior antitumor efficacy and safety in a preclinical model of peritoneal metastasis

Peritoneal metastasis from gastrointestinal cancers has poor outcomes, and whole-abdominal radiotherapy (RT) is limited by toxicity to radiosensitive organs. Spatially fractionated radiotherapy (SFRT) delivers heterogeneous doses, potentially sparing normal tissue while stimulating antitumor immunity. This study aime...

Sung Eun Lee, Changhoon Choi, Yeeun Kim et al. · 0 citations

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